14 best niacinamide serums 2025, tried & tested
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Certainly the unsung hero of my own personal skincare regimen, niacinamide serums are just as important to me as my trusty hyaluronic acid. From smoothing out the texture of my skin to keeping it hydrated and helping me deal with the aftermath of yet another PCOS-associated breakout, it's safe to say that vitamin B3 has become a non-negotiable ingredient of my daily routine.
“Niacinamide is a non-irritating, water-soluble vitamin that integrates well into daily skincare routines,” explains Dr Nora Jaafar — cosmetic and medical dermatology doctor at Rejuvenation Clinic. “Given its gentle profile, it's totally safe for long-term, daily application — even for sensitive skin types.”
But as is the case with most beauty products, I'm also not going to sugarcoat the fact that finding the best niacinamide serum isn't always an easy task. Take it from me: I've tried enough irritation-inducing formulas to know exactly what you need to keep in mind to avoid any unwanted mishaps. With the help of the GLAMOUR team, I've curated an edit of all the best (and most effective) niacinamide facial serums for every skin type and budget – tried and tested by yours truly.
How we test niacinamide serums:
Over the years, the GLAMOUR editors have tested countless self-proclaimed “best” niacinamide serums – ranging from affordable to premium formulas – on different skin types. When reviewing any face serum, we always aim to keep in mind various criteria, including but not limited to: how quickly we saw results, whether it resulted in any irritation and if it worked well underneath makeup or other skincare products. After something else? Shop the best vitamin C serums, best ceramide serum, best peptide serum and best hydrating serum.
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Why you can trust me:
It's my literal job to test beauty and wellness products, from azelaic acid serums to PDRN serums and eyelash growth serums. A result of attending events, getting eyes on new releases before anyone else and speaking to hundreds of experts around the ingredients and formulas best suited to different skin types and tones, I'm more in-tune with what's worth your money than your average beauty fanatic. I've tested hundreds of products over the course of my career, and some of the best are featured in this guide.
Ahead, the 14 best niacinamide serums of 2025, approved by GLAMOUR editors.
What is niacinamide?
A form of vitamin B3 commonly found in meat, fish, milk, eggs, and green vegetables, niacinamide is an essential vitamin that helps with cell health and energy metabolism. Also a popular skincare ingredient, its anti-inflammatory qualities mean it's great for helping with acne, eczema, and rosacea — but it's also just generally great for maintaining healthy-looking skin as a whole.
What are the benefits of niacinamide in skincare?
“Niacinamide is a form of vitamin B3, a multitasking antioxidant that can help soothe, firm and hydrate the skin, reverse the signs of aging (including fine lines and wrinkles), lighten dark spots and redness as well as reduce inflammation and stimulate collagen production — which may benefit conditions like acne and rosacea,” shares Deanne Robinson, MD, a board-certified dermatologist in Westport, Connecticut.
Not to mention, niacinamide is known to pair well with other active ingredients. “Niacinamide is a soothing ingredient, so it can help make an exfoliating ingredient or product more tolerable to sensitive skin, allowing you to use it more frequently and see the benefits of it,” she says. “Because of these properties, it pairs well with retinols and alpha hydroxy acids, or AHAs.”
Otherwise, niacinamide can also enhance the hydrating benefits of humectants — think the best hyaluronic acid serums and glycerin — so it’s a winner in moisturisers, too. “It works by preventing evaporation of moisture from the skin into the environment,” Dr. Robinson explains. In other words, it helps support our delicate moisture barriers too.
Heads up: to maximise the benefits of niacinamide, sunscreen is essential, so make sure you follow up your serum with a product that has at least SPF 30, which is the minimum amount recommended by the American Academy of Dermatology. Simply apply a few drops to the palm of your hand morning and evening, apply after cleansing and toning, and follow with a moisturiser and your trusty face SPF. Bottom line: There’s no reason not to slot this powerhouse topical ingredient into your skincare routine.
What is the best percentage of niacinamide?
“Clinical studies suggest that niacinamide is effective at concentrations between 2-5%, with proven benefits including improved barrier function, reduced transepidermal water loss, and control of sebum production," explains Dr Nora Jaafar — cosmetic and medical dermatology doctor at Rejuvenation Clinic. "Concentrations of 10% or more can also be really beneficial, but they come with an increased risk of irritation — particularly in individuals with sensitive skin.”
Can all skin types use niacinamide?
Niacinamide is well-tolerated across all skin types — but some will benefit from using it more than others. "It's particularly beneficial for those with acne-prone or oily skin, as it helps regulate sebaceous gland activity, and reduce inflammatory lesions," Dr Nora explains.
Can you use niacinamide with vitamin C?
While outdated research sometimes suggests the opposite, we can assure you that you're totally fine to use modern formulations of niacainamide and vitamin C together. “Niacinamide has anti-inflammatory and skin barrier-enhancing properties — while vitamin C (ascorbic acid) functions as a potent antioxidant and collagen-stimulating agent,” Dr Nora explains. “When used together, they can provide complementary benefits for brightening and photoprotection.”
Can I use niacinamide every day?
In short — yes. "Studies show that consistent use — both morning and evening — can enhance barrier function, regulate oils, and reduce oxidative stress," Dr Nora adds.
Looking to take your skincare routine to the next level? Check out our guides for the best eye creams, best moisturisers, best face washes and the best cleansers with salicylic acid.













